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For emergency, please call 911 or go to the nearest emergency room.
At Wholesome Clinic, we offer Spravato® — a cutting-edge, FDA-approved treatment designed for individuals living with treatment-resistant depression and major depressive disorder with suicidal thoughts.
If you’ve tried two or more antidepressants without relief, Spravato offers new hope. This fast-acting therapy is administered in a safe, supportive environment by our clinical team with expertise in advanced psychiatric care.
Spravato is the brand name for esketamine, a nasal spray form of ketamine that works differently from traditional antidepressants. Rather than targeting serotonin or dopamine, Spravato affects the glutamate system, a key neurotransmitter network involved in learning, memory, and mood.
This unique mechanism helps rapidly restore brain connections disrupted by depression — leading to faster, more profound improvements in mood and functioning.
Unlike oral medications that take weeks to work, Spravato delivers relief within hours to days for many patients. It helps rewire brain circuits affected by chronic depression, offering both symptom relief and improved resilience.
1. Comprehensive Evaluation
Your journey begins with a thorough mental health assessment. We’ll review your medical and treatment history, assess for eligibility, and develop a personalized care plan.
2. In-Clinic Treatment Sessions
Spravato is self-administered as a nasal spray, but only under direct medical supervision. The initial course includes:
3. Post-Dose Monitoring
After each treatment, you’ll stay in a comfortable recovery area for about two hours for monitoring. Side effects such as dizziness, disconnection, or drowsiness are typically mild and short-lived.
Improves quality of life, helping you reconnect with your daily routine, relationships, and goals.
You may be a candidate for Spravato if:
✔ You’ve tried two or more antidepressants without improvement
✔ You experience persistent or severe depression
✔ You’ve had thoughts of self-harm or suicidal ideation despite treatment
We’re here to guide you through every step — with compassion, privacy, and expertise.
In-Person: Administered at our Plano, Texas clinic
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